---
title: VarSome - Variant Views | Malorye Branca
description: Learn about the latest discoveries in genomics.
---

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# Variant Views

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![Picture of Malorye Branca](https://variants.varsome.com/hubfs/mabranca.jpg)

# Malorye Branca

[![](https://variants.varsome.com/hubfs/GV_1200x628_ClinicalResearch-1.jpg)](https://variants.varsome.com/en/many-children-with-variations-leading-to-cardiomyopathy-not-being-screened)

 Primary Reference: Ware, S. M. et al. JAHA, April 2021. Genes: This study examined 37 genes from clinical cardiomyopathy genetic testing panels. A University at Buffalo (UB)-led study on genes associated with pediatric cardiomyopathy strongly...

[Variant Views](https://variants.varsome.com/en/tag/variant-views)

##### [Many Children with Variations Leading to Cardiomyopathy Not Being Screened](https://variants.varsome.com/en/many-children-with-variations-leading-to-cardiomyopathy-not-being-screened)

 By [Malorye Branca](https://variants.varsome.com/en/author/malorye-branca#blog-listing-section) on May 5, 2021

[![](https://variants.varsome.com/hubfs/Icon%20comment.svg) 0](https://variants.varsome.com/en/many-children-with-variations-leading-to-cardiomyopathy-not-being-screened#comments-listing)

[Continue Reading](https://variants.varsome.com/en/many-children-with-variations-leading-to-cardiomyopathy-not-being-screened)

[![](https://variants.varsome.com/hubfs/GV_1200x628_LabApplication.jpg)](https://variants.varsome.com/en/pot1-regulates-proliferation-and-confers-sexual-dimorphism-in-glioma)

 Primary Reference:Jalali, A et al. Cancer Research. March 29, 2021. Genes: POT1 Germline POT1 mutations are linked to increased risk in a spectrum of cancers. This group recently identified a series of novel germline POT1 mutations that...

##### [POT1 Regulates Proliferation and Confers Sexual Dimorphism in Glioma](https://variants.varsome.com/en/pot1-regulates-proliferation-and-confers-sexual-dimorphism-in-glioma)

 By [Malorye Branca](https://variants.varsome.com/en/author/malorye-branca#blog-listing-section) on April 26, 2021

[![](https://variants.varsome.com/hubfs/Icon%20comment.svg) 0](https://variants.varsome.com/en/pot1-regulates-proliferation-and-confers-sexual-dimorphism-in-glioma#comments-listing)

[Continue Reading](https://variants.varsome.com/en/pot1-regulates-proliferation-and-confers-sexual-dimorphism-in-glioma)

[![](https://variants.varsome.com/hubfs/GV_1200x628_ClinicalResearch.jpg)](https://variants.varsome.com/en/lig3-variants-cause-a-novel-mitochondrial-neurogastrointestinal-encephalomyopathy)

 Primary Reference: Bonara, E. et. Al. Brain, April 15, 2021. Genes: LIG3 A team of scientists, led by Mariko Taniguchi-Ikeda from Fujita Health University Hospital, describes a set of seven patients with a novel mitochondrial disorder caused by...

[Variant Views](https://variants.varsome.com/en/tag/variant-views)

##### [LIG3 Variants Cause a Novel Mitochondrial Neurogastrointestinal Encephalomyopathy](https://variants.varsome.com/en/lig3-variants-cause-a-novel-mitochondrial-neurogastrointestinal-encephalomyopathy)

 By [Malorye Branca](https://variants.varsome.com/en/author/malorye-branca#blog-listing-section) on April 19, 2021

[![](https://variants.varsome.com/hubfs/Icon%20comment.svg) 0](https://variants.varsome.com/en/lig3-variants-cause-a-novel-mitochondrial-neurogastrointestinal-encephalomyopathy#comments-listing)

[Continue Reading](https://variants.varsome.com/en/lig3-variants-cause-a-novel-mitochondrial-neurogastrointestinal-encephalomyopathy)

[![](https://variants.varsome.com/hubfs/GV_1200x628_LabApplication.jpg)](https://variants.varsome.com/en/wgs-reveals-13-possible-new-alzheimers-disease-targets)

 Primary Reference:Prokopenko, D. et al. Azheimer’s & Dementia, April 2, 2021. Genes:FNBP1L, SEL1L, LINC00298, PRKCH, C150RF41, C2CD3, KIF2A, APC, LHX9, NALCN, CTNNA2, SYTL3, and CLSTN2. Researchers say they have performed the first study using...

[Variant Views](https://variants.varsome.com/en/tag/variant-views)

##### [WGS Reveals 13 Possible  New Alzheimer's Disease Targets](https://variants.varsome.com/en/wgs-reveals-13-possible-new-alzheimers-disease-targets)

 By [Malorye Branca](https://variants.varsome.com/en/author/malorye-branca#blog-listing-section) on April 12, 2021

[![](https://variants.varsome.com/hubfs/Icon%20comment.svg) 0](https://variants.varsome.com/en/wgs-reveals-13-possible-new-alzheimers-disease-targets#comments-listing)

[Continue Reading](https://variants.varsome.com/en/wgs-reveals-13-possible-new-alzheimers-disease-targets)

[![](https://variants.varsome.com/hubfs/GV_1200x628_ClinicalResearch-1.jpg)](https://variants.varsome.com/en/results-of-two-large-scale-studies-of-putative-breast-cancer-genes)

 Primary Reference #1: Breast Cancer Association Consortium, N. Eng. J. Med., Feb. 4, 2021. Genes: ATM, BARD1, BRCA1, BRCA2, CHEK2, MSH6, NF1, PALB2, PTEN, RAD51C, RAD51D, TP53, and more. To better define the genes associated with breast cancer...

[Variant Views](https://variants.varsome.com/en/tag/variant-views)

##### [Results of Two Large-Scale Studies of Putative Breast Cancer Genes](https://variants.varsome.com/en/results-of-two-large-scale-studies-of-putative-breast-cancer-genes)

 By [Malorye Branca](https://variants.varsome.com/en/author/malorye-branca#blog-listing-section) on April 5, 2021

[![](https://variants.varsome.com/hubfs/Icon%20comment.svg) 1](https://variants.varsome.com/en/results-of-two-large-scale-studies-of-putative-breast-cancer-genes#comments-listing)

[Continue Reading](https://variants.varsome.com/en/results-of-two-large-scale-studies-of-putative-breast-cancer-genes)

[![](https://variants.varsome.com/hubfs/GV_1200x628_ClinicalResearch-1.jpg)](https://variants.varsome.com/en/the-evolving-landscape-of-biomarker-testing-for-nsclc-in-europe)

 Primary Reference: Kerr, KM et al. Lung Cancer, April 1, 2021. Genes: ALK, BRAF, EGFR, ERBB2/HER2, FGFR, KRAS, NRG1, NTRK, MET, RET, ROS1. Cancer biomarker testing varies across Europe, and the field is rapidly advancing. This paper provides a...

[Variant Views](https://variants.varsome.com/en/tag/variant-views)

##### [Biomarker Testing for NSCLC in Europe](https://variants.varsome.com/en/the-evolving-landscape-of-biomarker-testing-for-nsclc-in-europe)

 By [Malorye Branca](https://variants.varsome.com/en/author/malorye-branca#blog-listing-section) on March 29, 2021

[![](https://variants.varsome.com/hubfs/Icon%20comment.svg) 0](https://variants.varsome.com/en/the-evolving-landscape-of-biomarker-testing-for-nsclc-in-europe#comments-listing)

[Continue Reading](https://variants.varsome.com/en/the-evolving-landscape-of-biomarker-testing-for-nsclc-in-europe)

[![](https://variants.varsome.com/hubfs/GV_1200x628_BioInformatics.jpg)](https://variants.varsome.com/en/polygenic-background-modifies-penetrance-of-monogenic-variants-for-tier-1-genomic-conditions)

 Primary reference: Fahed et al. Nature Communications, August 20, 2020. Genetic conditions: Familial hypercholesterolemia, hereditary breast and ovarian cancer, Lynch syndrome and others. "Genetic variation can predispose to disease both through...

[Variant Views](https://variants.varsome.com/en/tag/variant-views)

##### [Polygenic Background Modifies Penetrance of Monogenic Variants for Tier 1 Genomic Conditions](https://variants.varsome.com/en/polygenic-background-modifies-penetrance-of-monogenic-variants-for-tier-1-genomic-conditions)

 By [Malorye Branca](https://variants.varsome.com/en/author/malorye-branca#blog-listing-section) on March 9, 2021

[![](https://variants.varsome.com/hubfs/Icon%20comment.svg) 0](https://variants.varsome.com/en/polygenic-background-modifies-penetrance-of-monogenic-variants-for-tier-1-genomic-conditions#comments-listing)

[Continue Reading](https://variants.varsome.com/en/polygenic-background-modifies-penetrance-of-monogenic-variants-for-tier-1-genomic-conditions)

[![](https://variants.varsome.com/hubfs/GV_1200x628_ClinicalResearch.jpg)](https://variants.varsome.com/en/massively-parallel-functional-testing-of-msh2-missense-variants-conferring-lynch-syndrome-risk)

 Primary reference: Jia et al. AJHG. Jan. 7, 2021. Gene: MSH2. Lynch syndrome is mainly caused by variants in the DNA mismatch repair factors MSH2, MLH1, MSH6, and PMS2. While patients with a family history of this type of cancer can get screening,...

[Variant Views](https://variants.varsome.com/en/tag/variant-views)

##### [Massively Parallel Functional Testing of MSH2 Missense Variants Conferring Lynch Syndrome Risk](https://variants.varsome.com/en/massively-parallel-functional-testing-of-msh2-missense-variants-conferring-lynch-syndrome-risk)

 By [Malorye Branca](https://variants.varsome.com/en/author/malorye-branca#blog-listing-section) on March 8, 2021

[![](https://variants.varsome.com/hubfs/Icon%20comment.svg) 0](https://variants.varsome.com/en/massively-parallel-functional-testing-of-msh2-missense-variants-conferring-lynch-syndrome-risk#comments-listing)

[Continue Reading](https://variants.varsome.com/en/massively-parallel-functional-testing-of-msh2-missense-variants-conferring-lynch-syndrome-risk)

[![](https://variants.varsome.com/hubfs/GV_1200x628_BioInformatics-1.jpg)](https://variants.varsome.com/en/evidence-for-28-genetic-disorders-discovered-by-combining-healthcare-and-research-data)

 Primary reference: Kaplanis, J. et al. Nature, Oct. 14. 2020. Conditions: Developmental disorders. To identify previously undescribed genes associated with developmental disorders, researchers have integrated healthcare (clinical record) and...

[Variant Views](https://variants.varsome.com/en/tag/variant-views)

##### [Evidence for 28 Genetic Developmental Disorders Found by Combining Healthcare and Research Data](https://variants.varsome.com/en/evidence-for-28-genetic-disorders-discovered-by-combining-healthcare-and-research-data)

 By [Malorye Branca](https://variants.varsome.com/en/author/malorye-branca#blog-listing-section) on March 5, 2021

[![](https://variants.varsome.com/hubfs/Icon%20comment.svg) 0](https://variants.varsome.com/en/evidence-for-28-genetic-disorders-discovered-by-combining-healthcare-and-research-data#comments-listing)

[Continue Reading](https://variants.varsome.com/en/evidence-for-28-genetic-disorders-discovered-by-combining-healthcare-and-research-data)

[![](https://variants.varsome.com/hubfs/GV_1200x628_ClinicalResearch-1.jpg)](https://variants.varsome.com/en/genetic-mechanisms-of-critical-illness-in-covid-19)

 Primary reference: Pairo-Castineira, et al. Nature. Dec. 11, 2020. Featured genes: OAS1, OAS2, OAS3, TYK2, DPP9, IFNAR2. Since lung inflammation drives mortality in critical illness caused by Covid-19, host genetic variants associated with this...

[Variant Views](https://variants.varsome.com/en/tag/variant-views)

##### [Genetic Mechanisms of Critical Illness in Covid-19](https://variants.varsome.com/en/genetic-mechanisms-of-critical-illness-in-covid-19)

 By [Malorye Branca](https://variants.varsome.com/en/author/malorye-branca#blog-listing-section) on March 4, 2021

[![](https://variants.varsome.com/hubfs/Icon%20comment.svg) 0](https://variants.varsome.com/en/genetic-mechanisms-of-critical-illness-in-covid-19#comments-listing)

[Continue Reading](https://variants.varsome.com/en/genetic-mechanisms-of-critical-illness-in-covid-19)

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